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In the present study, we established a dry eye model in vitro and in vivo to elucidate whether AST inhibits ferroptosis via regulating SLC7A11/GPX4 and activates autophagy to protect against DED

To address the ROS burst driven by ferroptosis and the imbalance of iron homeostasis, a study has developed a macrophage-targeting polysaccharide iron nanoenzyme, which possesses dual enzyme activities resembling catalase and peroxidase, capable of scavenging ROS, inhibiting lipid peroxidation, and controllably releasing Fe 2 to correct systemic iron deficiency [150]

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