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It was observed that azide produced graded increases in ROS signaling, accompanied by graded decreases in contraction that were reversible, demonstrating that mitochondria respond to graded hypoxia by increasing the generation of ROS and suggesting that cytochrome oxidase may contribute to this oxygen sensing mechanism [71]

In pathological states where localized or systemic copper excess contributes to hypertrophy, copper chelators can alleviate oxidative stress and subsequent remodeling [12]

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Advances in astrocyte-neuron metabolic interaction research are uncovering mechanisms by which these cells maintain brain homeostasis