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Due to the complexity, and size limitations associated with the cobalamins, the primary method for calculating ground state properties is density functional theory (DFT), while time-dependent DFT (TD-DFT) is used for electronically excited states

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Appendix 1 describes the literature search strategy

Unlike subcutaneous fat, which lies just beneath the skin, visceral fat surrounds vital organs and drives inflammation, insulin resistance, fatty liver disease, and cardiovascular risk