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Significantly higher levels of activated NK cells were observed in the TME of tumors with high PKMYT1 expression over tumors with low PKMYT1 expression [135]

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In contrast, Th17 cell polarization is promoted by TGF and interleukin (IL)-6 [12]

However, the recovery of these regenerative capabilities (by increased expression of NAMPT for example) change the physiology of the cells towards stem-like cells, gaining some cancer properties, such as unlimited proliferative capacity, altered metabolism, DNA-repair, methylation alterations, with phenotype similar to CSCs, which deregulation by any other mutation initiate the tumor