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By definition, transferrin saturation (TS) values greater than 50% in males and greater than 45% in females are defined as elevated

Cardiovascular effects Oxidative stress-induced intracellular redox imbalance plays a pivotal role in the pathogenesis of various cardiometabolic risk factors (hyperlipidaemia, hypertriglyceridemia, hyperglycemia, hypertension, obesity) leading to severe cardiovascular diseases

Adenosine 5-monophosphate (AMP)-activated protein kinase (AMPK) is a key regulatory protein of mitochondrial mass (117), and its activation significantly inhibits the activation and proliferation of RA-FLSs (118)