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For many of these approaches, clinical implementation is still far away because of different limitations, as recently reviewed by [6,7]

Chloroquine has been reported in one study to reduce antibody titers(108)

doi: 10.1556/018.68.2017.3.10 159 HopeW

Although we were successful in ectopically expressing CDO in our cell culture system, the absolute level of maximal expression for either of the CDO constructs was far less than what is normally found in vivo