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4.4 Interaction between clinical intervention and pathological mechanisms The preceding sections of this review have systematically elucidated how CKD induces and exacerbates sarcopenia through core mechanisms, including chronic inflammation and oxidative stress, accumulation of uremic toxins, metabolic acidosis, and hormonal dysregulation

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However, there is no doubt that, with the right guidelines, these are two extremely useful substances whose use, with due care, is recommended

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