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Masoom et al., 2018)

Clinically, patients with Fms-related tyrosine kinase 3 internal tandem duplication (FLT3-ITD) mutation are the largest subgroup of AML, which is associated with an increased relapse risk and decreased disease-free survival [24]

Additionally, their functions are linked to their cellular localization, which demonstrates an evolutionary relationship between the studied isoforms and their role in plant defense