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5 It is achieved at the genetic level by foreign gene expression of key products such as ECM or inhibition of disease-causing gene expression to delay disease progression, and commonly used vectors include viral vectors, nonviral vectors or gene editing to transport specific bioactive substances

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Thus, tissue distortions and the rates of tissue deformation associated with concussion (with no lingering neural or vascular structural changes visible in radiological imaging or pathology) are probably lower than those for more severe brain injuries (Gennarelli et al., 2003), so it is inappropriate to rely on a single threshold for all head injuries

Chondroitin sulfate (ChS) has been extensively used in biomedical and pharmaceutical fields