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However, with the markets enthusiasm for low-toxicity polypeptide extracts derived from traditional Chinese medicine, polypeptide tyrosinase inhibitors may be the main direction in the future

This can trigger an endothelial-to-mesenchymal transition (94), where the loss of endothelial-specific markers and gaining of a mesenchymal or myofibroblastic phenotype contribute to fibrosis development due to the generation of activated myofibroblasts (95)