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While excessive VEGF expression can lead to increased BBB permeability, controlled VEGF signaling has been shown to support the survival and function of endothelial cells that make up the BBB (Simons et al., 2016)

The pooled RR for sICH was 1.65 (95% CI: 1.212.23, p = 0.003), indicating a significantly higher risk of sICH in the EVT group