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These cells remain metabolically active, adopt a distinct phenotype (including chromatin changes), and critically secrete a variety of pro-inflammatory cytokines, proteases, growth-factors and extracellular-matrix modifying signals

ATO resistant cells are also resistant to melphalan and doxorubicin, but remain sensitive to darinaparsin, bortezomib and ABT-737

The physiological relevance of an electrochemical parameter measured under such artificial conditions may be questioned

Necrotic cell death after APAP overdose As discussed, proteins released from the mitochondrial inter-membrane space after APAP are also seen in the cytosol after apoptotic cell death