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CoQ10 scavenges free radicals produced by lipid peroxidation and prevents mitochondrial deformity during ischemic episodes, and may help maintain integrity of myocardial calcium ion channels during ischemic insults (2)

Danger signals, including cartilage degradation products, are recognized by synovial macrophages, activating pathways such as NF-B and triggering the release of pro-inflammatory cytokines (e.g., IL-1, TNF-, and IL-6) and chemokines

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