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There is overwhelming evidence that demonstrates that elevated calcium concentration, inflammation, increased oxidative stress, as well as a reduction in blood flow, are some of the pathophysiological mechanisms underlying NIHL (Figure 1

GSH is also a key determinant of redox signaling and protection against oxidative stress

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Brain Fog and Cognitive Impairment: By crossing the blood-brain barrier to restore cortical glutathione and modulate neurotoxic glutamate levels, NAC helps reduce the severe neuroinflammation that drives memory loss, confusion, and difficulty concentrating