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The SPR and recombinant-protein assays provide stronger evidence for a direct interaction than the earlier pathway studies

Research has documented modulation of nitric oxiderelated processes, reduction of oxidative damage, and suppression of neuroinflammatory responses

In such structural configuration, the two c-METs are placed in relatively close proximity, which enables their intracellular KDs to undergo autophosphorylation and thus initializing the downstream signaling (Fig