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[8] Similarly, patients with gout or hyperuricemia should avoid high niacin intake, as niacin (even in nicotinamide form) can raise uric acid levels and potentially trigger gout flares

A real-world comparison study found that oral semaglutide users lost an average of 3.64 kg in 6 months versus 5.26 kg for injectable users, though the difference was not statistically significant

For this article, best is evaluated across five criteria that matter to real people pursuing real fat loss outcomes: Total body weight reduction: The percentage of baseline body weight lost over a standardized time period