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Nanotechnology-based delivery systems including liposomes, SLNs, NLCs, and polymeric nanoparticles, partially overcome these limitations by enhancing dermal penetration, stability, and sustained release

Mol Cell Biochem 240:8398

Due to their favorable efficacy and tolerability profiles, SSRIs and SNRIs are widely recommended by international guidelines for managing perimenopausal affective symptoms (71,73)