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Taken together, the action of L-carnitine on OCTN2 translation alone may be sufficient to explain its preventive effect against lenvatinib-induced muscle toxicity

In response to metabolic or energetic stress, AMPK activity inhibits anabolic pathways, including cholesterol transport and progesterone biosynthesis, in part by regulation of steroidogenic proteins, including steroidogenic acute regulatory protein (STAR) and HSD3B ( Table 4 )

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Among the inflammatory molecules examined, G-CSF, GM-CSF, IFN-2, IL-3, and IL-8 were elevated, while IL-17 was decreased in this AD group, highlighting a distinct pro-inflammatory profile of AD with low tocopherol levels