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Here, we review several issues that may be considered controversial in the field, considering each line of evidence independently and in the light of all other lines of evidence

GPx isoenzymes are all antioxidant enzymes that reduce potentially damaging reactive oxygen species (ROS), such as hydrogen peroxide and lipid hydroperoxides, to harmless products like water and alcohols by coupling their reduction with the oxidation of glutathione (Figure 2a )

334 Interfering RNA or antisense RNAbased therapy constitutes another method to suppress the Wnt/-catenin pathway, showing suppressive effect to HCC in vitro 335,336 and in mouse models

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