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A broader methodological review reports that SUMO proteases maintain high cleavage fidelity across diverse conditions, temperature (437 C), pH (5.510.5), detergents, 2 M urea, tolerate various fusion partners, and rarely show off-target cleavagethough they cannot cleave proteins containing N-terminal proline immediately following the SUMO fusion [72,145]

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Vitamin C treatment can promote survival and maintain proliferation while protecting stem cells from DNA damage and senescence, whereas in cancer cells, the reactivation of tumor suppressors can reduce cell viability and alter sensitivity to therapeutic agents