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The alteration of glutamate in CSF, blood and brain tissue related to synthesis, metabolism and reuptake into neuronal or glial cells is linked to decreased glutamate in the subgenual of anterior cingulate cortex associated with reduced connectivity with insula and decreased BOLD response to emotional stimuli in MDD patients (139)

The Phase IIb work culminated in the oral OPTIONS study

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In contrast to TGF-RI inhibition, SMAD silencing did not counteract the TGF-2-evoked suppression of p-c-MET