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doi: 10.1016/j.bbrc.2006.12.195

The brain consumes a massive amount of oxygen and is highly susceptible to oxidative stress, which manifests clinically as severe brain fog, memory impairment, and neuroinflammation

Frailty syndromes might result in the following: poorer response to somatic and/or psychiatric stressors, increased risk of hospitalization, adverse disease outcomes, hospitalization, and premature death (179)