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Weight Regulation In animal studies, AOD-9604 reduced body fat mass and improved metabolic parameters. Early human trials showed limited direct weight loss, but trends toward improved lipid metabolism. Key takeaway: May influence weight management indirectly by altering fat metabolism

Notable recent developments include the first preclinical study demonstrating NNMT inhibition improves cardiac function and reduces fibrosis in a heart failure model (Li et al., 2025), a comprehensive review of NNMT as a therapeutic target for neurodegenerative disorders (Liu et al., 2025), and emerging evidence that NNMT inhibition counteracts tubular senescence and fibrosis in chronic kidney disease