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In addition, exogenous NaB administration ameliorated renal function, glucose and lipid metabolic disturbance, inflammation, fibrosis and oxidative injury by activating Nrf2 via inhibiting the activity of HDAC in DN mice (Dong et al., 2017

On top of that, it can also reduce the expression of pro-inflammatory cytokines, enhance antioxidant defenses via glutathione, and potentially reduce the production of reactive oxygen species (free radicals) (2-4)