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Conversely, supplementation with exogenous -KG or its analogs enhances mTORC1 activation in nave CD4+ T cells, upregulating the transcription factor T-bet and driving Th1 differentiation (71)

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Interestingly, the study also showed that cytokine production in human lung slices and human BAL fluid from in vivo studies after treatment with LPS are correlated (58), reinforcing the applicability of PCLS in investigating the molecular pathways of pulmonary inflammation