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However, the role of thioredoxins in the protection against oxidative stress in these subjects is not clear and warrants further study

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The term MCD alludes to the biological function of mast cells in producing histamine

Published studies have largely focused on the role of the genetic component in the development of PAH, and the most common genetic mechanism is mutation in bone morphogenetic protein receptor 2 (BMPR2) [7], while the means of epigenetic alterations such as DNA methylation, noncoding RNAs, and histone methylation and acetylation in PAH are currently receiving increasing attention [89]