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Description

The SOS response of bacteria is a complex gene network for DNA repair induced by DNA damage [47]

4a-e, Supplementary Data 1): (i) 3xTG, displaying both amyloid plaque and tau tangle pathologies 27 , and (ii) BiGenic (BiG) mice, generated by crossing 5xFAD with N40K transgenic mice recapitulating both amyloid pathology and the newly discovered U1 snRNP splicing dysfunction in AD 45

Fractions containing SF3B1 were pooled together, washed with PBS and concentrated in an Amicon Ultra-4 Centrifugal Filter Unit (Sigma-Aldrich, UFC801024)