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Betaine, also known as trimethylglycine, is a naturally occurring metabolite that serves as a methyl donor and osmolyte in the body

& Boulos, P

However, any perturbations or disturbances in this adaptive process can lead to the development of GDM (69)

At least for presynaptic terminals of cortico-striatal synapses, calcium influx from internal calcium stores was shown to prevent presynaptic BDNF release mediated via presynaptic NMDA receptors containing the GluN1 subunit (Park 2018) (Fig