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Combined effect of coenzyme Q10 and fenofibrate on forearm microcirculatory function in type 2 diabetes

Together, our findings reveal how modest sequence divergence within a conserved architectural motif can drive functional specialization of transcriptional coactivators, providing insight into the evolution of transcriptional regulation and its adaptation to pathogenic lifestyles

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For OCR, 1.5 mol/L oligomycin (ATP synthase inhibitor), 2 mol/L FCCP (mitochondrial uncoupler) and 0.5 mol/L rotenone/antimycin A (Complex I/III inhibitors) were sequentially added to the culture plate and maximal respiration and non-mitochondrial respiration values derived from OCR kinetics were recorded