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Interestingly, the mutation of ATP4Ap.R703C leads to gastric acid deficiency, and the disturbance of pH balance can directly affect the physiological function of the mitochondrial respiratory chain, causing ROS signaling to be activated and triggering caspase-3-mediated apoptosis in the host cells (Bentez et al., 2020)

10.1016/j.jcis.2017.11.064 8 CaoX.WangN

As such, more research is needed to understand whether an overdose is possible, the signs and symptoms associated with it, and the safest way to treat it