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The authors concluded that Hg can trigger genotoxicity, autoimmunity, oxidative damage, and be involved in the pathogenesis of AIT, hypothyroidism, and thyroid cancer (TC) (62)

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Long-term opioid administration eventually reaches a dose ceiling that is attributable to the rapid onset of analgesic tolerance coupled with the slow development of tolerance to the untoward side effects of respiratory depression, nausea and decreased gastrointestinal motility