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[DOI] [PMC free article] [PubMed] [Google Scholar] 20.(U.S.) IoLARGuide for the Care and Use of Laboratory Animals

One-carbon metabolism requires B vitamins, and hence the efficient dietary supply may protect against cancer by reducing DNA instability and by affecting DNA methylation [42], but vitamin B12, methylcobalamin, and coenzyme B12 were found to enhance DNA methylation in the presence of S-adenosylmethionine for concentrations up to 1 M, but at higher concentrations, these compounds were found to inhibit DNA methylation [43]