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The transcription factors HIF-1, facilitating hypoxia, MTF1, facilitating ATP7B and metallothionein expression and the ncRNA miR-21-5p, decreasing FDX1 expression are accompanied to reduce the sensitivity to Cu stress beyond small molecule compounds (Figure 5

doi:10.1002/art.20460 Dervieux T, Kremer J, Lein DO, Capps R, Barham R, Meyer G, Smith K, Caldwell J, Furst DE (2004b) Contribution of common polymorphisms in reduced folate carrier and gamma-glutamylhydrolase to methotrexate polyglutamate levels in patients with rheumatoid arthritis

E.OrmanM.ShimadaK.et al (2014)