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Additionally, DAPA reversed the altered expression of ferroptosis-related genes at both the mRNA and protein levels: The decreased expression of GPX4, SLC7A11 and FTH-1 in renal tissues of the si-Nrf2 group was improved by DAPA, while the elevated expression of TFR-1 was inhibited by DAPA (Fig

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Further analysis revealed that iron suppresses TREM2 expression by disrupting the binding of these proteins to rs75932628, and that downregulation of TREM2 by iron, as well as other heavy metals, inhibits the expression of glutathione peroxidase 4 ( GPX4 )

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