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RL-GenRisk shows superior performance for ccRCC risk gene prioritization over existing methods To assess the performance of RL-GenRisk, we utilized RL-GenRisk and eight other existing methods to identify ccRCC genes with gene mutation data of ccRCC patients from The Cancer Genome Atlas (TCGA) 45 and five different PPI networks

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Immune profiling showed decreases in regulatory T cells (CD4 + CD25 hiFoxp3 +) and nave T cells (CD45RO-CD62L +) in the VOR/HCQ group, suggesting improved anti-tumor immunity, although this did not result in clinical advantage