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For instance, the activation of JNK can lead to the phosphorylation of cAMP response element-binding protein (CREB), a critical transcription factor that promotes BDNF expression

doi: 10.1152/ajpendo.00578.2012

Bottom line: Topical glutathione is a helpful addition to a skincare routine, but the most effective way to support your skin's radiance and cellular health is by boosting your internal levels through highly bioavailable, liposomal delivery

Each of the current treatment approaches have their positive and negative attributes in terms of the impact that they have on the microenvironment, but on top of this, there are considerations including the location and accessibility of the TME which all play a role in how the damaged microenvironment can be reversed