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Most researchers find the 8mg to 12mg transition more manageable than the 4mg to 8mg transition, possibly because the GI system has already adapted to substantial receptor agonism

10.1046/j.1365-313X.2003.01901.x 58 MittlerR.VanderauweraS.GolleryM.Van BreusegemF

doi: 10.3390/antiox11020232

It has been shown that - and -tocopherols form short-chain metabolites, - and -carboxyethyl hydroxychroman and carboxymethylbutyl hydroxychroman, which substantially scavenge ROS and RNS in the cytosol [97]