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The addition of XAV939 significantly attenuated the restorative effects of Miln and Van on miRNA-124 expression, decreasing its expression by 58.2% and 37.8% compared to their XAV939-free counterparts, respectively

Interestingly, not all the strains experienced a synergistic effect

These DAMPs stimulate Pattern Recognition Receptors (PRRs) and the NLRP3 inflammasome, promoting persistent neuroinflammation (91)

Similarly, composite IVD replacements that combine various biomaterial strategies to mimic the native disc structure, including organized annulus fibrosus and NP components, have shown promise