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Interestingly, SIAH2 deficiency in female mice leads to a phase-advanced circadian liver transcriptome and altered lipid rhythms, revealing an intriguing sex-specific role for UPS regulation in circadian rhythms, whose cause remains unknown (Mekbib et al., 2022)

10.1002/cam4.349 Cancer Med

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The fluorescent signal was normalized to the total cell number, and cystine uptake levels were expressed as a percentage relative to control (DMSO)-treated vector cells