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Once outside the cell, GSH degradation occurs exclusively in the extracellular space and only on the surface of cells that express the ectoenzyme -glutamyl transferase

Studies suggest that methionine supplementation can affect DNA methylation, with both positive and negative effects depending on the gene region affected (Waterland, R., 2006)

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Such therapeutics would be mimetics of the pathogen-binding domains of host complement regulators, preventing pathogens from hijacking host complement or eliciting complement regulators to inhibit complement activation (50)