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Am J Physiol-cell Physiol

Differential Outcomes in Codon 12/13 and Codon 61 NRAS-Mutated Cancers in the Phase II NCI-MATCH Trial of Binimetinib in Patients with NRAS-Mutated Tumors

Similar to the early-stage model, tissue inhibitor of metalloproteinases-1 (TIMP-1) levels were also reduced, while TIMP-2 and inflammatory markers (macrophages, MCP-1) showed no significant changes