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Future efforts should focus on the development of brain-penetrant inhibitors, rational combination therapies, and predictive biomarkers to facilitate clinical translation

Toxicol Lett 218(3):299307 Oikawa S, Hirosawa I, Tada-Oikawa S, Furukawa A, Nishiura K, Kawanishi S (2006) Mechanism for manganese enhancement of dopamine-induced oxidative DNA damage and neuronal cell death