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Additionally, a decreased response to oral methionine has been observed in men older than 45 years (Silberberg et al, 1997)

Low levels of B12 fatigue and weakness constipation loss of appetite and weight loss problems with balance depression problems with thinking a sore mouth or tongue In infants, signs of a deficiency include: not growing or developing at the expected rate problems with movement megaloblastic anemia Anemia and neurological problems can lead to further symptoms and complications