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For example, researchers have applied proteomic approaches to identify novel biomarkers, such as plasma sRAGE for detecting presence and progression of emphysema [33], whereas others have adopted metabolomics approaches to identify potential disease severity markers or therapeutic candidates such as purines [8], sphingolipids [2], and glycerol phospholipids [4]

Of these, 20 received a L-carnitine supplement ( 100/kg/mg/day) for 45 days, while the other 20 received a placebo

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