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The stacking approach is the most common protocol in the research community for this reason

Phosphorylated VEGFR-2 promotes mitosis and proliferation of endothelial cells by activating the MAPK pathway and PKC-MAPK bypass (47)

Though the protection is localized to the ER, it potentially extends to the cytosol by preventing consumption of reduced glutathione (discussed below), which is a major cytosolic and mitochondrial antioxidant