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In the past four decades, the global prevalence of AD has sharply risen, especially in developed countries (4)

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A search performed on October 2020 in the databases Pubmed and Web of Science, using the terms: skin microbiota, skin microbiome, psoriasis, and humans. Observational human studies and clinical trials that evaluated the skin microbiota or microbiome composition in psoriasis patients and in those of healthy controls using cultivation-independent methods, written in English, were included

BRD4 is known to regulate the expression of c-Myc oncogenes, and targeting bromodomains in melanoma inhibits their expression [244]