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The duration of benefits also varies by delivery method

Amber Lavigne, Newcastle

Targeting the ER stress pathways by gene therapy approach is considered as a novel and promising direction in neuroprotective strategies

Following a single intravenous bolus dose of 0.5 mg/kg in 10 children 4 to 8 years old, the half-life was 5.8 1.6 hours, the average clearance was 0.042 0.01 L/hr/kg, the volume of distribution during the terminal phase (V ) was 0.34 0.12 L/kg and the volume of distribution at steady state (V ss) was 0.26 0.08 L/kg