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The presumptive zygotes were then cultured and divided into groups, to which 5 (Leo5, n = 101), 10 (Leo10, n = 99), 20 (Leo20, n = 103), 40 (Leo40, n = 98), and 60 (Leo60, n = 96) M, and 0 (Con, n = 109) M leonurine were supplemented to the groups in sequence