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It traces the transition from traditional oxygen-based detection (first generation) to mediator-based electron transfer (second generation) and finally to direct electron transfer between the enzyme and electrode (third generation)

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F2-Isoprostanes F2-Isoprostanes are prostaglandin-like compounds formed by the non-enzymatic peroxidation of arachidonic acid by free radicals and are considered reliable biomarkers of in vivo lipid peroxidation [148]

reported that human astrocytes induced the expression of CXCL9-11, NF-B, and p38MAPK phosphorylation, as well as receptors of neurotransmitters, such as the melanocortin 2 receptor, cholinergic receptor nicotinic gamma subunit, purinergic receptor, gamma-aminobutyric acid (GABA) A receptor 1, and epidermal growth factor receptor 2, which are involved in synaptic transmission and CNS disorders [95]