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The likely-resulting endotoxemia from intestinal barrier dysfunction stimulates toll-like receptor 4 (TLR4) in Kupffer cells to produce NADPH-oxidase (NOX)-dependent ROS [213] and activate HSCs, leading to fibrosis [144, 219]

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The GTT1 class contains TmGst5, TmGst6, and TmGst7

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The importance of mitochondrial pyruvate carrier in cancer cell metabolism and tumorigenesis

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Lower doses (600mg) show benefit but with reduced magnitude

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